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As environmental factors, gut microbiota performs critical functions in the pathogenesis of AS through various mechanisms, including interacting with genes, enhancing intestinal permeability, activating the gut mucosa immune system, and affecting the intestinal microbiota metabolites

J Biol Chem 284:1160111612 Chung WJ, Sontheimer H (2009) Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-B

Glutathione supports mitochondrial function, so when reserves are stretched thin, cells simply have less energy to work with

Abundant evidence shows that mitochondrial dysfunction, which can be induced by aging, genetics, and nutritional predispositions, plays a critical role in the pathogenesis of glaucoma.[7, 911, 14, 42] This includes not only focal, but also systemic mitochondrial dysfunction