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They also reported that baseline upregulation of HIF-1 and peroxisome proliferator-activated receptor- (PPAR) in these cells may contribute to the transcriptional activation of PDK4

Enzyme and protease Enzymes are key participants in various biological processes, both normal and disease-related, including cancer, stroke, infection

Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015