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The influx and subsequent accumulation of copper within cellular compartments are instrumental in orchestrating the cascade of events that constitute cuproptosis

Niacinamide operates along similar lines: it reduces oxidative stress through its antioxidant activity but also has a function of reducing hyperpigmentation by inhibiting transfer of the pigment melanin from melanocytes to keratinocytes (it interrupts the transfer of vesicles known as melanosomes)

Dixit SG, Rani P, Anand A, Khatri K, Chauhan R, Bharihoke VJRf