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Mayo Clin Proc 61: 978996

6.0 6.1 6.2 "The Types of EDS"

neoformans secretes extracellular urease to modulate phagosomal pH, which in turn promotes the conditions necessary for melanization, persistence in phagocytic cells, and eventual traversal of the blood-brain barrier 34

Heme binding protein genes (44 out of the studied 121 genes) were also enriched in the upregulated gene set, while Fe-S cluster protein genes (14 out of the studied 43 genes) were enriched in the downregulated gene set (Additional file 2)