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Patients and caregivers should also receive timely and up-to-date education about immunotherapies, their mechanism of action, and the clinical profile of possible irAEs prior to initiating therapy and throughout treatment and survivorship

These pharmacokinetic challenges necessitate the development of innovative delivery systems such as nanoparticles, liposomes, and solid lipid carriers to enhance their stability, absorption, and targeted delivery of flavonoids (Billowria et al., 2024

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The propensity score was kept in the final model regardless of its significance levels