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doi: 10.1172/JCI31422

We hypothesized that patients with stable schizophrenia would exhibit a reduction in glutathione, glutamate, and/or glutamine in the cerebral cortex, consistent with a post-inflammatory response, and that this reduction would be most marked in patients with residual schizophrenia, in whom an early stage with positive psychotic symptoms has progressed to a late stage characterized by long-term negative symptoms and impairments

Tissues were homogenized and lysed in T-per Tissue protein extraction reagent (78510, Thermo Fisher Scientific) using a bead homogenizer for 3 min at maximum speed (Qiagen, TissueLyser II) for total tissue protein