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The few subcellular fractionation datasets that are available have been suggestive of only minor NADP redox changes at dark-light changes in the cytosolic fractions, which appears in stark contrast to pronounced NADP redox dynamics in the chloroplast, and indeed NAD redox dynamics in the cytosol 36,37,38

It should be noted that GCLM KO mice have systemic GSH deficiencies, ranging from 10 to 40% of normal levels depending on the tissue type 16