glutathione molecular weight kda Panel A. SDS-PAGE analysis of the fractions collected from Tested Reactivity Anti-Glutathione Synthetase antibody [EPR6562] (ab124811)

Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy

These gene sets were not enriched in GPX4 perturbed cells in the absence of giredestrant, consistent with the screen results that identified GPX4 as a giredestrant-dependent vulnerability (Supplementary Fig

(n = 2)

As an additional control, growth inhibition assays were conducted on the antimalaria compounds artemisinin and chloroquine: the IC 50 values obtained (12 nM and 22 nM, respectively) are comparable to previously published results ( Supplementary Figure 6 )