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5-Caffeoylquinic acid (chlorogenic acid) is one of the most abundant and widespread soluble phenolics among vascular plants ( p -coumaryol quinic acid was first suggested in carrot cell cultures, and studies of the impact of the expression of the hydroxycinnamoyl quinic acid gene in tobacco and tomato plants demonstrated that this route may be predominant in the Solanaceae family ( TDR4 -silenced tomato fruit revealed a significant reduction in 5-caffeoylquinic acid levels (61%) (Table 2)

& Ouzounis, C

This results in most of the drug disposition occurring in the central regions of the lungs instead of reaching the peripheral areas where they are most required in achieving the most therapeutic benefit