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Although xCT expression is confined to the plasma membrane in normal tissues (36,39), it is upregulated in certain types of cancer, such as colorectal cancer, malignant glioma and non-small cell lung cancer, which increases cystine uptake (4042)

This suggests that SLC7A11 not only plays a critical role in protein and GSH synthesis through cysteine uptake but also dictates glutamine dependence 61

Recent studies have observed that cepharanthine is capable of inhibiting the interaction between TSHR.132 (TSH receptor peptide) and HLA-DR1-Arg74, thus blocking T cell activation and cytokine response in a Graves disease-relevant humanized mouse model expressing HLA-DR3 (Li et al

Future development requires transdisciplinary nanotechnology, plant physiology, soil biogeochemistry, and environmental science research to address key uncertainties in nanomaterial interactions, fate and specific application protocols