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It was important to note that reduction in body weight did not appear to reach a plateau at the end of the treatment and all significant reduction in weight from baseline was seen in all groups administered cagrilintide, in comparison to the placebo group

Melting transitions of RNA measured by fluorescence The fluorescence of the aptamers was measured at different temperatures using a Fluoromax 4C (Horiba) with a Peltier-controlled temperature attachment (Model F-3004, Horiba)

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the inventors have developed and has successfully clinically tested a safe, stabilized, orally bioavailable formulation of GSH