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Expressed in the B cell compartment of mice, LMP1 causes fatal lymphoma if T cell-mediated immune surveillance is suppressed at the same time 10,11

Abbreviations GCLC: Glutamate cysteine ligase catalytic subunit GCLM: Glutamate cysteine ligase modifier subunit GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species C1q: Complement component 1q C3: Complement component 3 GSDMD: Gasdermin D GSDME: Gasdermin E DAM: Disease associated microglia DAA: Disease associated astrocyte Iba1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei HO1: Hemeoxygenase 1 CCL: CC Chemokine ligand CXCL: C-X-C motif ligand AD: Alzheimers disease App: Amyloid precursor protein A: Amyloid beta App : NL-G-F App knockin mouse NL-G-F References Guo, C., Sun, L., Chen, X

doi: 10.1016/j.carbpol.2020.116958 137 LimJMYooHJLeeKW

Diabetes 63:20732085 van Diepen JA, Jansen PA, Ballak DB, Hijmans A, Rutjes FP, Tack CJ, Netea MG, Schalkwijk J, Stienstra R (2016) Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes