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In severe COVID-19, as a consequence of cell death and tissue damage, intracellular ferritin is released out of the cells, with excess ferritin accumulating in the body to form hyperferritinemia (Kell and Pretorius, 2014)

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The system consists of a heterodimer composed of the light chain xCT (SLC7A11) and the heavy chain 4F2 (SLC3A2), which mediates a 1:1 exchange between intracellular glutamate and extracellular cystine

BCA also exerts a neuroprotective effect against L-glutamate-induced cytotoxicity, which plays a crucial role in neuronal cell death in various neurodegenerative diseases 44,45 while PHL, a -dicarbonyl enols scavenges electrophile metal ions & unsaturated aldehyde through their nucleophile enolate form and becomes a rational candidate for treatment of oxidative stress linked disorders 45,46