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The BBB Is a Validated Target for the Treatment of SAE Sepsis is an abnormal or dysregulated host response to stimuli from external factors as well as internal organ dysfunction (Lelubre and Vincent, 2018)

Furthermore, there is direct evidence that VEC ferroptosis promotes AS by accelerating endothelial dysfunction during ROS-mediated lipid peroxidation [12]

Our research results revealed that cardiac function in mice significantly decreased 4 weeks after the first treatment of PD-1 inhibitor (two cycles), with reductions in both EF and FS, which is consistent with previous studies (Xia et al., 2020)

By modulating dopaminergic pathways, melatonin may affect AH production (through dopamine DA1 receptors) and outflow (through dopamine DA2-3 receptors) (65)