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In parallel, metal-based agents derived from ruthenium, iron, and platinum continue to advance through experimental clinical evaluation for cancer, and ferroquine (5) has reached clinical testing for malaria (Figure 4) (Nriagu and Skaar, 2015)

Trifluoperazine N --D-glucuronide was procured from Cerilliant (Round Rock, TX, USA), and naloxone 3- O- -D-glucuronide was acquired from Sussex Research Laboratories Inc