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CVDs are the leading cause of death in patients with MASLD, whereas liver-related mortality is confined to patients with advanced fibrosis, with the risk rising exponentially as the fibrosis stage increases [6]

o Neuroinflammation: -viniferin treatment led to a significant decrease in brain uptake of a PET tracer for neuroinflammation (TSPO tracer [18F] DPA-714) compared to resveratrol

A theoretical multi-target strategy might combine: NAD+ for ongoing metabolic support: sirtuin activation, DNA repair, mitochondrial maintenance, nutrient sensing recalibration Epitalon for periodic telomere maintenance: cyclic telomerase activation to preserve replicative capacity and delay senescence onset This combination would address at least seven hallmarks between the two interventions

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