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Two further phase II trials (280, 281) with larazotide acetate failed in finding an improvement in intestinal permeability, whereas the last trial published (282) underlined possible usefulness in refractory CD, defined as malabsorption and continued villous atrophy on duodenal biopsies despite strict avoidance of gluten for a minimum of 12 months (283)

By supporting the activity of gamma-aminobutyric acid (GABA), a key neurotransmitter, magnesium reduces overactivity in the brain and promotes a sense of calm, making it easier to fall asleep

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