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Agents such as pembrolizumab and dostarlimab, particularly in combination with carboplatin and paclitaxel, have improved progression-free and overall survival rates for patients with MMR-deficient tumors

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62 In addition to their ability to generate HETEs via a similar process as described above for 5-LOX, 12-LOX and 15-LOX also generate LXs, oxo-ETEs, and dihydroxyeicosatetraenoic acids (diHETEs)

At the same time, the field acknowledges real limitations heterogeneous trial designs, industry-funded studies, and copper's inherent toxicity at higher concentrations that responsible researchers should factor into any study design