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Another common autoimmune comorbidity of hypertension is vitiligo

Collective findings from these studies underscore persistent translational challenges, including size heterogeneity, rapid renal clearance, and limited long-term toxicological data, highlighting the need for improved targeting, surface modification, and synthesis control to support clinical translation [91, 190]

22,23 Historically, varicocele has been thought to cause infertility by reducing oxygenation and increasing oxidative stress in the testicular environment, but more recent evidence also implicates inflammatory and immune mechanisms