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64 Similarly, the phosphorylation of 1,4,5-inositoltrisphosphate receptor-associated cGMP kinase substrate, a protein located in the membrane of the endoplasmic reticulum, in a ternary complex initiates the inhibition of the IP 3 -induced release of Ca 2+ from the endoplasmic reticulum, which promotes the relaxation of VSMCs

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It is widely accepted that the initial wave of C-fiber activity in phase 1 leads to phase 2, which depends on the inflammatory response and central sensitization

J.BerdoukasV.KaragiorgaM.LadisV.PigaA.AessoposA.et al (2006)