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It consists largely of three amino acids: glutamine, glycine, and cysteine

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

This approach not only produces synergistic effects across these levels but also enhances drug delivery efficiency and mucosal retention through the use of natural polymeric materials, thereby comprehensively improving the efficacy of 5-ASA ( FIGURE 2 2.2 Combination of TCM formulations and 5-ASA: holistic multi-target regulation The combination of TCM formulations with 5-ASA demonstrates multidimensional synergistic advantages in clinical efficacy, mechanisms of action, and safety, significantly expanding the scope of disease management beyond conventional 5-ASA monotherapy

The resulting BsAb harnesses receptor-mediated transcytosis (RMT) to cross the BBB: after TfR engagement and entry into early endosomes, the antibody is ferried across endothelial cells and released into the parenchyma [118]