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This has been studied primarily in cultured cells and animal models

Nitric oxide (NO) secretion was measured using the Griess reagent

In summary, being safe in patients with the inflammatory bowel disease, and devoid of toxic effects (LD1 could be not achieved, limit test negative) (21), gastric pentadecapeptide BPC 157 consistently counteracts analgesia in the mice placed on a hot plate and treated with morphine or morphine + haloperidol