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It generates NADPH , which is critical for maintaining glutathione in its reduced form (GSH), protecting RBCs from oxidative damage

Several studies have demonstrated that epigenetic modification of SELENBP1 through promoter methylation results in its downregulation [82]

Longitudinal studies in spontaneously hypertensive stroke-prone have demonstrated that gut dysbiosis precedes the onset of hypertension and is marked by shifts in bacterial community structure and altered tryptophan-kynurenine metabolism, implicating microbial pathways in the early development of hypertension and related neurovascular complications (Shi et al., 2022)

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