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This modification reduces renal clearance, theoretically allowing lower daily doses to maintain sustained serum levels

Figure 2: Changes in Body Weight (%) from Baseline to Week 72 in Study 2 in Patients with Obesity or Overweight and Type 2 Diabetes Note: Based on average percent weight change of each randomized patient within each specific treatment arm from 100 imputed datasets including observed data and imputed data using hybrid approach for missing values

Research shows this mechanism gives insights into fat metabolism, muscle health and NAD+ biology

Activated microglia drive demyelination via CSF1R signaling