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However, the mechanistic rationale for combining these agents is sound and warrants further investigation

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Moreover, these lesions exhibited many histopathologic features of human pLGGs

This oversight is consequential: serine and glycine supply one-carbon units for nucleotide biosynthesis in proliferating fibroblasts [1], glutamine fuels macrophage activation and fibroblast collagen secretion [10, 11], arginine is the substrate for nitric-oxide-mediated vasodilation [12], and cysteine underpins glutathione synthesis, buffering the oxidative burst characteristic of the inflammatory phase of wound healing [13]