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In its strict sense, chronobiotics refer to agents capable of entraining or phase-shifting circadian rhythms through direct action on the central or peripheral clocks, with melatonin representing the prototypical example (Zawilska et al., 2009)

People with alcohol dependence or chronic illnesses Those taking certain medications that interfere with B12 absorption, including metformin and proton pump inhibitors

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This structure primarily includes proteins such as D-box-binding protein (DBP), thyrotroph embryonic factor (TEF), and hepatic leukemia factor (HLF) (Mitsui et al., 2001)