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This process involves includes many mechanisms at nanoscale (gene expression), mesoscale (changes in enzymes, ion channels, cytoskeletal proteins, receptors and secreted molecules) to macroscale (neuropathy) levels with the final common consequence of the lost retinal output to the brain (Figure 1)

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas

Funding This work was supported by the National Natural Science Foundation of China (82172656, 81902550, 81802476), and the Natural Science Foundation of Hunan Province (2021JJ40882)

The increase in paw volume was calculated by subtracting the initial paw volume (basal) to the paw volume measured at each time point