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It is noteworthy that the age-old Hippocratic belief that all disease originates in the gut remains relevant in modern neurobiology, with growing evidence supporting the importance of the gut-brain axis in maintaining neural well-being (130)

Studies demonstrate that esculin (50-200 mol/l) can disrupt the interaction of the Kelch-like ECH-associated protein 1 (Keap1), a key negative regulator of the Nrf2 signaling pathway, with Nrf2 to activate the Nrf2 signaling pathway (54,55)