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Conclusion: The results obtained with the creation of the EsPIO scale show very high negative predictive values that are comparable to other scales validated in other studies to detect LVO Disclosure of interest: No disclosures E-Posters - PRE-HOSPITAL SERVICE ORGANISATION 09.00 - PRE-HOSPITAL SERVICE ORGANISATION - 09.01 - PRE-HOSPITAL SERVICE ORGANISATION P2627 - ESOC25-2430 ABOARD THE MOTHERSHIP: EARLY CLINICAL EXPERIENCE WITH DIRECT TO THROMBECTOMY PATHWAY Chak Lam Ip 1 , Jonathan Hayton 2 , Selina Edwards 1 , Sohaa Jamil 2 , Ken Crossley 3 , Rajaram Bathula 2 , Soma Banerjee 2 , Rob Simister 1 1 University College London Hospitals NHS Foundation Trust, London, United Kingdom, 2 Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom, 3 London Ambulance Service NHS Trust, London, United Kingdom Background and Aims: In London, suspected strokes are directed to the nearest hyperacute stroke unit (HASU), but not all offer mechanical thrombectomy

They modulate brain function, neuroplasticity, memory consolidation, and stress response

Standard allometric scaling would suggest a far lower human-equivalent dose

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