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Until relatively recently, the answer was, well, nothing really

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Data availability The authors declare that all the data supporting the findings of this study are available within the article and Supplementary Information files which contains synthetic procedures and NMR spectra for the featured compounds, additional functional data at rodent and human receptors, biological protocols for receptor binding, activity and antinociception assays

If you notice any irritation or unusual symptoms, discontinue use and consult your provider