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Through a systematic review, we identified that oxidative stress played a significant role in the pathogenesis of OA, and metformin had potential antioxidative capacity in relieving various chronic inflammation-related diseases, raising the possibility of treating OA

For example, in cases of glucose6-phosphate dehydrogenase deficiency, there is increased avidity of the EGR for FAD, resulting in EGR AC values within the normal range, even in the presence of clinical signs of riboflavin deficiency (Thurnham, 1972)

The results of a systematic review demonstrated the non-beneficial effect of CaMg infusions for the prevention of oxaliplatin-induced peripheral neuropathy

Also, serum levels of oestradiol (E2) and progesterone were improved in PCOS women after NAC consumption (Reference Nasr9)