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When RHIM2 ZBP1 is occupied, the free RHIM1 ZBP1 domain can recruit RIPK1 and/or RIPK3, eventually leading to the recruitment of effector molecules, completing the assembly of the PANoptosome and driving PANoptosis [74]

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Interestingly, we found that efficient phase transfer from water to dichloromethane only occurs in the pH range of 6.09.6, at which the amine groups in DDA are protonated (positively charged) and the carboxylic acid groups in GSH are deprotonated (negatively charged) supporting the electrostatic nature of the HIP in DDA-GSH-AuNCs (Fig