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5 Conclusions 1) This retrospective study provides the first in vivo evidence that DARA monotherapy, beyond its cytotoxic effects, modulates the secondary enzymatic functions of CD38 in MM, altering ADO and INO production and supporting a model of antibody-driven purinergic remodeling

Other innovative approaches, including cell-based regenerative therapies (bemdaneprocel), novel drug delivery systems, and gastrointestinal-focused treatments ( Lactobacillus acidophilus ), aim to address both motor and non-motor symptoms of PD

Several nano-based approaches have potential to reverse the MS pathogenesis probably by decreasing the proinflammatory load, increasing the anti-inflammatory mediators and suppressing the immune system