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Without sufficient B12, one's energy levels can plummet , leading to fatigue and lethargy

Th1 cells drive cellular immunity and released pro-inflammatory cytokines such as IFN-, IL-1, IL-12, and TNF- [17]

As a result, targeting a single metabolic pathway may not lead to sustained therapeutic responses, as compensatory mechanisms can activate other pathways, undermining the treatments efficacy

Beyond that, those with AITD (autoimmune thyroid disease) are at increased risk of other autoimmune diseases like Sjgrens syndrome in which the salivary glands are affected