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Recent research provided a deeper understanding of this notion, revealing that carbohydrate metabolism could adapt to the hypoxia condition in mild preeclampsia while a decompensation of carbohydrate metabolism reprogramming was discovered in severe preeclampsia (11) (Figure 2)

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High cerebral guanidinoacetate and variable creatine concentrations in argininosuccinate synthetase and lyase deficiency: implications for treatment