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The one or more hepatocyte growth factor mimics have a general structural formula , -R 3 -R 3 -NH-(CH 2 ) ir C-NH 2 1 2 3 where i is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

These pro-inflammatory factors further damage the barriers and alter the microbiota, perpetuating the cycle of chronic inflammation ( Bacteroidetes and Firmicutes , and an upturn in Proteobacteria ( CB , FP , Clostridium lavalense , Clostridium cluster XlVa , Blautia faecis , Bacteroides uniformis , Ruminococcus torques , and Roseburia inulinivorans ( Based on existing research, intestinal Clostridium and their metabolites exert effects on IBD mainly via intestinal barrier repair, innate immunity regulation, and adaptive immunity modulation ( Clostridium -containing preparations also exhibit certain adjuvant therapeutic effects ( 3.1.1 Repair intestinal barrier and stabilize gut microbiota homeostasis Intestinal barrier dysfunction initiates IBD