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doi: 10.1016/j.tem.2021.12.001, 87 Moreno-YruelaC.ZhangD.WeiW.BaekM.LiuW.GaoJ.et al

Routine testing of vitamin B12 levels in metformin-treated patients should be considered. Because metformin often causes digestive tract upset, many patients are also put on a proton pump inhibitor (PPIs) such as esomeprazole ( Nexium ), lansoprazole ( Prevacid ) or omeprazole ( Prilosec )