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Therefore, there is an urgent need to build specialized spectral libraries for CDMs but experimentally measuring MS/MS spectra of CDMs at a repository scale remains unrealistic

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The present study showed that the concomitant use of VPA with liver enzyme-inducing AEDs, including phenytoin, carbamazepine, and phenobarbital, also led to a higher incidence of hyperammonemia than VPA monotherapy

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Therefore, direct intramuscular implantation combined with intrathecal injection may be more effective and need to be assessed in future trials

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