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In brief, the striatal tissues were homogenized using a Dounce homogenizer in a final 20-fold dilution of ice-cold meta-phosphoric acid solution (MPA, 3%) and EDTA (1 mM)

Combining EGCG and a therapeutic gene in a multifunctional nanocarrier significantly increased spatial learning and memory capacities in APP/PS1 and wild-type mice, suggesting that co-delivering these molecules may be highly effective in AD treatment [47]