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Description

Prototype Clearance: The prototype drug typically becomes undetectable in plasma within 4 hours post-administration

Timing: Typical research protocols administer capsules either fasted (30 minutes before food) or with light meal

However, using the best techniques can dramatically slow down this process

An external material must penetrate both the LPS layer and outer membrane porins, which are passive diffusion channels that prevent larger molecules from permeating [18]