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2.1.3.2 Preventing muscle loss and preserving insulin sensitivity Both Astragalus and yam have demonstrated protective effects against diabetes-related muscle wasting by modulating mitochondrial function through the Rab5a/mTOR signaling axis (35)

Research demonstrates that BPC-157 upregulates vascular endothelial growth factor receptor-2 (VEGFR2) at both mRNA and protein levels in endothelial cells without increasing VEGF-A itself, instead sensitizing cells to existing VEGF signaling while simultaneously activating the Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway