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10.1007/s00424-010-0862-9 35 DuniA.LiakopoulosV.RoumeliotisS.PeschosD.DounousiE

Sims NR, Muyderman H (2010) Mitochondria, oxidative metabolism and cell death in stroke

Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

5), and that the expanded polyQ proteins associate with, and linger within, IFD inclusions in proteostressed neurons (Fig