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Clin Chem 30:16311636 Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function

Its also essential for normal brain and nerve function

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Then, PRB, a strong transactivator in response to progesterone, loses its dominant position in the secretory nuclei, thus inducing progesterone resistance and leading to repeated implantation failure (5, 10)