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Clinical evidence, as summarized in Table 1, includes studies showing that Empagliflozin improved oxidative stress markers and NYHA functional class in T2DM patients with HFrEF (Eshraghi et al., 2025), and Dapagliflozin reduced the number of AHREs and improved oxidative stress/mitochondrial function in the clinical AF subgroup of patients with CIEDs (Nantsupawat et al., 2024)

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Transl Oncol (2020) 13(7):100777

Furthermore, GSH transport is governed by diverse mechanisms, including synergistic interactions with ABC transporters and GSHs association with other molecules (e.g., reduced GSH involves in MRP1 transport)