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Additionally, patients should be observed for signs and symptoms of megaloblastic anemia, such as fatigue, pallor, and anorexia

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These reductive shifts in the cytoplasmic [NAD + ]/[NADH] and [NADPH]/[NADP + ] with aging corresponded very well with the reductive shifts found with aging in the total brain NAD + /NADH and NADPH/NADP + in C57BL/6J mice ( While performing metabolome analysis of 10 brain regions of C57BL/6N mice over 4 time points across the lifespan, another group studying aging-related metabolite level changes in the brain found very different results in how the pyruvate levels changed with aging ( + ]/[NADH] with aging ( In the human brain, the total NAD + /NADH, as measured by magnetic resonance imaging (MRI) of NAD + and NADH, was shown to become more reduced with aging (Zhu et al., 2015)