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We thank Shuyun Tian for the assistance in the early stage of the project

These layers facilitate the mixing of nutrients through convection currents, where warmer, less dense water rises, while colder, denser water sinks

Data were imputed by random draw from a normal distribution with default parameters: 0.3 width and 1.8 downshift

These substitutions were capable of altering the specificity of individual substrates for their cognate kinases in predictable ways, an effect that was driven largely, but not completely, by alteration of the K M values (Extended Data Fig