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However, its efficacy is reduced due to strong hydrogen bonding between its phenolic -OH group and polar phospholipid heads (Shah et al., 2019)

This interaction can occur by itself, but occurs at a much faster rate with the assistance of a group of enzymes call the Glutathione-S-Transferases (GST)(figure1) (5)

After intravenous injection, the system efficiently accumulated in tumors

Inhibition of xCT exacerbates AngII-induced cardiac hypertrophy and increases the levels of Ptgs2, a biomarker of ferroptosis, malondialdehyde and ROS [85]