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or an N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof, with the proviso that: when R 3 is ethyl, R 1 and R 2 cannot be both H, O, or when R 3 is ethyl and at least one of R 1 or R 2 is H, R 1 or R 2 cannot be In one aspect of this embodiment, the compound has the structure of formula (II): R 3 is independently selected from the group consisting of H, C 1-12 aliphatic, C 1-6 -alkyl-aryl and C 1-6 -alkyl-heteroaryl

Fielding, R., Riede, L., Lugo, J

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doi: 10.1016/j.bone.2015.05.025 90