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Enterotoxigenic Escherichia coli is phagocytosed by macrophages underlying villus-like intestinal epithelial cells: modeling ex vivo innate immune defenses of the human gut

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Yet ER client protein oxidation must be tightly regulated, because over-exuberant oxidation can cause the formation of disulfide-bonded protein aggregates, and can also prevent proteins from achieving the correct disulfide bonded configuration, for which the ability to reduce and reform (i.e., isomerize) disulfide bonds is needed

What that longer-term care looks like: Medication-assisted treatment (MAT): FDA-approved medications including buprenorphine (Suboxone) and naltrexone (Vivitrol) reduce cravings and can help prevent return to use