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ALA/DHLA can also maintain cellular antioxidant status indirectly by inducing the absorption of other antioxidant molecules or enhancing the synthesis of endogenous antioxidants, such as vitamin C (ascorbic acid) and, indirectly, vitamin E, or antioxidant enzymes and the ratio of reduced/oxidized glutathione (GSH/GSSG) [25] (Figure 3)

This comprehensive metabolic shift results in enhanced lipid utilization (lower cellular fat accumulation) and an efficient use of nutrients, echoing the metabolic effects of calorie restriction or exercise at the cellular scale

The obese rats were treated with tesofensine for 16 days, and they showed significant weight loss compared to rats given a placebo